Noopept Review—Is It a Worthwhile Nootropic?

We had to do a Noopept review as soon as we heard about it. This racetam analogue has been getting very popular. And the claims sound amazing — improved memory and learning, better focus, supercharged creativity. Does it really hold up? Let’s find out!

What Is Noopept?

Noopept is the brand name for N-phenylacetyl-L-prolylglycine ethyl ester.  It was developed in Russia and it is only sold there (as well as offline). Its molecule is supposedly similar to that of Piracetam. The hype is that it can cross the blood-brain barrier more efficiently and produce the same effect in a fraction of the time.

Piracetam Basics

If you are not familiar with Piracetam – it is one of the oldest and safest nootropics we know of. It was first used back in the 1950’s. So far, we don’t know of any serious short or long-term consequences to using it. Unlike other nootropics, Piracetam was created with cognitive enhancement in mind. It is great for learning and memory, especially verbal memory.

The problem with Piracetam is that its effects can take up to two weeks to kick in. They are also quite mild. You might not feel any different at all. The other issue is we still don’t know how it works. Some have hypothesized that it improves your neuron “excitability”. Other have associated it with NMDA receptors that are key to memory and learning.

Piracetam is routinely prescribed in Europe and Asia. It is a prescription-only drug but a quite popular one among doctors. In the US, Piracetam is completely forbidden. The FDA has approved it – neither as a drug nor as a supplement.

My personal experience with Piracetam has been unimpressive. It did make me slightly more focused and perhaps it helped with studying. Mostly, it caused mildly annoying headaches (these can be helped if you supplement choline). It should be noted that I only used it for less than two weeks and the effects can take more than that. Frankly, I was just disappointed with it and I did not want to continue taking it. Which brings me to the main difference between Noopept and Piracetam:

Noopept Should Work Faster

Noopept users and vendors boast that it is 1000 times more potent than Piracetam. Which is not hard, considering the fact that you need 2,4-4,8 grams of Piracetam to even get any effect. Compare that to the 10-30mg dose of Noopept. It quickly becomes obvious that it’s much stronger.

But…

There Has Been Very Little Research On Noopept

Well, very little research on humans anyways. If you are the kind of person that likes to dig through PubMed, you will notice how little information there is on there. What is more, all of the research comes from the same bunch of Russian authors. Most of them are members of the Russian Academy of Medical Sciences, which is a very respected institution. Still, experiments usually have better value if they can be repeated by a team in a different laboratory.

And to make matters even more obscure, Noopept was first reported in 1996. A team of Russian scientists synthesised N-acylprolyl-containing dipeptides and looked into their effect on memory loss. One of those chemicals was Noopept, and they hypothesised it was a prodrug of Cyclo-L-prolylglycine. Cyclo-L-prolylglycine is a neuropeptide (a peptide that affects your nervous system) and it is thought to be the peptide to which Piracetam owes its action.

But remember, we do not fully understand Piracetam, either. Whether the neuropeptide that Noopept turns into is the reason behind Piracetam’s benefits can’t be said with any measure of certainty.

Besides, that same team of Russian chemists and neurologists are the only ones that have done systematic research on Noopept. Most of those experiments were on animal models. Rats. To be fair, some small studies have been conducted on humans, too. So far the results are very promising. Still, we have no large-scale research nor do we have the years of experience that we have with Piracetam.

It is quite likely that Noopept turns out to be a very efficient and useful drug. Nootropics are not just for smart people to feel smarter, they are mostly for patients with cognitive decline. Noopept is a new hope for them. Still, as of 2017, it is only prescribed in Russia and it is not very well-researched.

Noopept Review: Anecdotal Evidence

Here are the main benefits that users have noticed:

  • Memory enhancing properties – Noopept makes learning easier. Processing information becomes a breeze, especially after a few days of using the drug. Piracetam mostly affects verbal memory but there have been no such reports about Noopept.
  • Creativity boost – Some  Noopept fans have suggested that it helps your brain’s hemispheres to communicate more efficiently. Not only does this improve creativity but it can also make your quality of life significantly better.
  • Neuroprotective power – This has actually been researched. Much like Piracetam, Noopept seems to protect your neurones from oxidative stress. It might also boost your Nerve Growth Factor and thus contribute to neurogenesis.

If you are looking into Noopept, you should probably consider what you want it for. As you can see, the main benefit has to do with memory and learning. This can come in super handy during finals but not much use if you are trying to finish a work project. Unlike other popular nootropics, Noopept does not give you increased energy. You will still have to sleep for at least 8 hours a day and maintain a great diet, or else you might negate the benefits of the drug.

Noopept Dosage

noopept review

Vendors recommend taking 10-30 mg of Noopept daily for best results. This is a relatively low dose which is great. What is not that great is we do not know much about the pharmacodynamics and pharmacokinetics of Noopept. In plain English? We don’t know for sure how it behaves in your system.

For most drugs, peak plasma levels and half-life are basic facts you can find with a simple Google search. Noopept has hardly been researched. In Russia, they sell it in 10mg tablets. Doctors who prescribe it often have to tweak the dosage until they find what works for their patient. This is a great time for me to remind you that I am not a doctor (nor a medical professional) and none of this article is intended as medical advice. You will have to find your perfect dose on your own.

This is even trickier than it sounds. When you don’t know how long the drug stays in your system (or when its levels peak), planning your consumption becomes virtually impossible. It is all about experimentation with Noopept. I don’t know your biochemical makeup and we are not so sure about the drug, either. Trial and error is the only way to figure out whether Noopept works for you and in what dose.

An Important Disclaimer About Noopept

If you do decide to take it, a choline supplement will be in order.

Remember those Piracetam headaches? Supposedly, they are a relatively rare side effect. In reality, most of the people I know that have used it experienced headaches.

Choline is incredibly important for brain health and proper cognitive function. It gets depleted when you use Piracetam (or any other racetam). If you don’t want headaches you will have to take choline.

Noopept Review: Should You Try It?

Noopept is a very novel nootropic. It has only been researched by one group of scientists (which were also the ones who discovered it). It is not approved by the FDA. The only place where they actually use it (for medical purposes) is Russia.

On the other hand, Noopept has some amazing benefits. It can increase memory, improve learning, make you more creative, less stressed, and happier. User reports have been overwhelmingly positive. Noopept is getting more and more popular each day.

So I wish I could tell you whether to get it or not. To be honest, I can’t decide. It is a matter of what you gain versus what you risk. With all nootropics, long-term effects have not yet been confirmed. Toxicitiy seems to be quite low for Noopept but then again there are only preclinical trials. Drug interactions as well as the way Noopept can affect any underlying conditions you might have. The list goes on and on.

Does any of this mean that Noopept is inherently dangerous? Of course not. It could be quite the opposite. Noopept can turn out to be the next nootropic superstar. And you can jump on that band wagon before it even gets popular (and prices rise). This would be cool, right?

Anyways, what I am trying to say that if you want to give it a go—do it. But first, please consider what you could be risking. With new drugs there is always the higher chance of them turning out to be dangerous.

As always, stay smart and safe! If you have any questions or thoughts on this Noopept review that you want to share, drop them in the comments below.

-Sam

PS: You can buy Noopept right here.

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